Endocrine System Physiology Set 1


Endocrine System 1


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1. A 46-year-old man has “puffy” skin and is lethargic. His plasma thyroid-stimulating hormone
concentration is low and increases markedly when he is given thyrotropin-releasing hormone. Which of
the following is the most likely diagnosis?

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2. After menopause, hormone replacement therapy with estrogen-like compounds is effective in
preventing the progression of osteoporosis. What is the mechanism of their protective effect?

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3. Which of the following is inconsistent with the diagnosis of Graves’ disease?

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4. A patient has an elevated plasma thyroxine (T4
) concentration, a low plasma thyroid-stimulating
hormone (TSH) concentration, and a thyroid gland that is smaller than normal. Which of the following is
the most likely explanation for these findings?

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5. Which of the following stimulates the secretion of parathyroid hormone (PTH)?

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6. A 40-year-old woman comes to the emergency room with a fracture in the neck of the femur.
Radiographs reveal generalized demineralization of the bone in the area. Her plasma calcium ion
concentration is significantly greater than normal: 12.2 mg/dL. Which of the following conditions is
consistent with this presentation?

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7. Which of the following changes would be expected to occur with increased binding of a hormone to
plasma proteins?

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8. Which of the following pairs is an example of the paracrine secretion?

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9. A man eats a low carbohydrate meal rich in proteins containing the amino acids that stimulate
insulin secretion. Which of the following responses accounts for the absence of hypoglycemia?

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10. Which of the following is most likely to produce the greatest increase in insulin secretion?

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11. Which of the following would be associated with parallel changes in aldosterone and cortisol

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12. Which of the following statements about antidiuretic hormone is true?

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13. Parathyroid hormone directly :

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14. A 40-year-old woman is placed on a high-potassium diet for several weeks. Which of the following
hormonal changes is most likely to occur?

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15. Which of the following hormones activate enzyme-linked receptors?

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16. Some cells secrete chemicals into the extracellular fluid that act on cells in the same tissue. Which
of the following refers to this type of regulation?

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17. Which of the following decreases the rate of urinary excretion of calcium ions by the kidney?

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18. Which of the following hormones is both synthesized and stored in the pituitary gland?

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19. Which of the following hormones is largely unbound to plasma proteins?

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20. Exposure to UV light directly facilitates which of the following?

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21. Which of the following anterior pituitary hormones plays a major role in the regulation of a
nonendocrine target gland?

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22. A 30-year-old woman is breast-feeding her infant. During suckling, which of the following
hormonal responses is expected?

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23. . A patient has a goiter associated with high plasma levels of both thyrotropin-releasing hormone
(TRH) and thyroid-stimulating hormone (TSH). Her heart rate is elevated. This patient most likely has
which of the following?

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24. A 55-year-old man has developed the syndrome of inappropriate antidiuretic hormone secretion due
to carcinoma of the lung. Which of the following physiological responses would be expected?

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25. Which of the following pairs of hormones and the corresponding action is incorrect?

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