Carbohydrates Biochemistry Set 5

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Biochemistry (Carbohydrates And Carbohydrate Metabolism Set 5)

MCQ

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1. Which one of the following compounds
cannot give rise to the net synthesis of
Glucose

A) Glycerol

B) Lactate

C) Acetyl CoA

D) α-ketoglutarate

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2. How many ATP molecules will be required
for conversion of 2-molecules of Lactic acid
to Glucose

A) 6

B) 4

C) 2

D) 8

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3. The reaction catalysed by phosphofructokinase

A) Is the rate-limiting reaction of the glycolytic pathway

B) Uses fruitose-1-phosphate as substrate

C) Is inhibited by fructose 2, 6-bisphosphate

D) Is activated by high concentrations of ATP and citrate

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4. Phenylalanine is the precursor of

A) Throxine

B) Histamine

C) L-DOPA

D) Tyrosine

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5. Phenylalanine is the precursor of

A) L-DOPA

B) Histamine

C) Tyrosine

D) Throxine

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6. Which of the following enzyme is not
involved in HMP shunt

A) Glucose-6-p-dehydrogenase

B) Transketolase

C) Glyceraldehyde-3-p dehydrogenase

D) Phosphogluconate dehydrogenase

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7. Which of the following statements
regarding T.C.A cycle is true

A) It is an anaerobic process

B) It occurs in cytosol

C) It is amphibolic in nature

D) It contains no intermediates for GluconeogenesisIt contains no intermediates for Gluconeogenesis

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8. In presence of the following cofactor,
pyruvate carboxylase converts pyruvate
to oxaloacetate

A) ATP, Protein and CO2

B) CO2 and ATP

C) Protein

D) CO2

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9. Which one of the following statements
concerning glucose metabolism is correct

A) Glucose enters most cells by a mechanism in which Na+ and glucose are co-transported

B) Pyruvate kinase catalyses an irreversible reaction

C) The conversion of Glucose to lactate occurs only in the R.B.C

D) An elevated level of insulin leads to a decreased level of fructose 2, 6-bisphosphate in hepatocyte

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10. The synthesis of glucose from pyruvate
by gluconeogenesis

A) Requires oxidation/reduction of FAD

B) Is inhibited by elevated level of insulin

C) Occurs exclusively in the cytosol

D) Requires the participation of biotin

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11. The reaction catalysed by phosphofructokinase

A) Is activated by high concentrations of ATP and citrate

B) Is the rate-limiting reaction of the glycolytic pathway

C) Uses fruitose-1-phosphate as substrate

D) Is inhibited by fructose 2, 6-bisphosphate

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12. The free energy change, AG

A) Can only be calculated when the reactants and products are present at 1mol/1 concentrations

B) Is equal to –RT in keq

C) Is directly proportional to the standard free energy change, AG

D) Is equal to zero at equilibrium

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13. The more positive the E0, the greater the
tendency of the oxidant member of that
pair to

A) Lose and gain electrons

B) Lose (or) gain electrons

C) Gain electrons

D) Lose electrons

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14. An allosteric enzyme responsible for
controlling the rate of T.C.A cycle is

A) Fumarase

B) Isocitrate dehydrogenase

C) Malate dehydrogenase

D) Aconitase

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15. How many ATPs are produced in the
conversion of phosphoenol pyruvate to
citrate

A) 4

B) 1

C) 2

D) 6

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16. An uncoupler of oxidative phosphorylation such as dinitropheno

A) Inhibits electron transport and ATP synthesis

B) Specially inhibits cytochrome b

C) Allow electron transport to proceed without ATP synthesis

D) Inhibits electron transport without impairment of ATP synthesis

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17. Which of the following reactions is unique
to gluconeogenesis

A) Oxaloacetate phosphoenol pyruvate

B) Phosphoenol pyruvate pyruvate

C) Lactate Pyruvate

D) Glucose-6-phosphate Fructose-6-phosphate

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18. Out of 24 mols of ATP formed in TCA cycle,
2 molecules of ATP can be formed at
“substrate level” by which of the
following reaction

A) Citric acid→ Isocitric acid

B) Succinic acid→ Fumarate

C) socitrate→ Oxaloacetate

D) Succinylcat→ Succinic acid

19 / 31

19. Which one of the following would be
expected in pyruvate kinase deficiency

A) Decreased ratio of ADP to ATP in R.B.C

B) Increased levels of lactate in the R.B.C

C) Increased phosphorylation of Glucose to Glucose-6-phosphate

D) Hemolytic anemia

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20. Compared to the resting state, vigorously
contracting muscle shows

A) Decreased concentration of AMP

B) Decreased oxidation of pyruvate of CO2 and water

C) An increased conversion of pyruvate to lactate

D) A decreased NADH/NAD+ ratio

21 / 31

21. All of the following statements about the
enzymic complex that carries out the
synthesis of ATP during oxidative
phosphorylation are correct except

A) It is located on the matrix side of the inner mitochondrial membrane

B) ) It can bind molecular O2

C) It can exhibit ATPase activity

D) It is inhibited by oligomycin

22 / 31

22. Electron transport and phosphorylation
can be uncoupled by compounds that
increase the permeability of the inner
mitochondrial membrane to

A) Protons

B) Electrons

C) Uncouplers

D) All of these

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23. Glycogen is present in all body tissues
except

A) Kidney

B) Brain

C) Stomach

D) Liver

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24. Under standard conditions

A) The free energy change ∆G°, is equal to 0

B) The standard free energy change ∆G, is equal to 0

C) The free energy change, ∆G°, is equal to the standard free energy change, ∆G°

D) Keq is equal to 1

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25. The conversion of pyruvate to acetyl CoA
and CO2

A) Depends on the coenzyme biotin

B) Involves the participation of lipoic acid

C) Occurs in the cytosol

D) Is reversible

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26. Reduced glutathione functions in R.B.Cs
to

A) Produce NADPH

B) Produce NADH

C) Reduce oxidizing agents such as H2O2

D) Reduce methemoglobin to hemoglobin

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27. Reduced glutathione functions in R.B.Cs
to

A) Reduce methemoglobin to hemoglobin

B) Reduce oxidizing agents such as H2O2

C) Produce NADH

D) Produce NADPH

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28. Cori cycle is

A) Synthesis of glucose

B) uptake of glycose

C) Both (A) & (B

D) reuse of glucose

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29. The glycolysis is regulated by

A) Hexokinase

B) All of these

C) Pyruvate kinase

D) Phosphofructokinase

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30. Glucokinase

A) Is widely distributed and occurs in most mammalian tissues

B) None of these

C) Is widely distributed in Prokaryotes

D) Has a high km for glucose and hence is important in the phosphorylation of glucose primarily after ingestion of a carbohydrate rich meal

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31. For conversion of oxaloacetate to
phosphoenol pyruvate, high energy
molecule is required in the form of

A) GTP (or) ITP

B) GTP only

C) None of these

D) ITP only

Your score is

The average score is 40%

Carbohydrates Biochemistry Set 5

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