Carbohydrates Biochemistry Set 5

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Biochemistry (Carbohydrates And Carbohydrate Metabolism Set 5)

MCQ

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1. Glucokinase

A) Is widely distributed and occurs in most mammalian tissues

B) None of these

C) Has a high km for glucose and hence is important in the phosphorylation of glucose primarily after ingestion of a carbohydrate rich meal

D) Is widely distributed in Prokaryotes

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2. Under standard conditions

A) The free energy change, ∆G°, is equal to the standard free energy change, ∆G°

B) The free energy change ∆G°, is equal to 0

C) The standard free energy change ∆G, is equal to 0

D) Keq is equal to 1

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3. Reduced glutathione functions in R.B.Cs
to

A) Reduce oxidizing agents such as H2O2

B) Produce NADPH

C) Reduce methemoglobin to hemoglobin

D) Produce NADH

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4. Which one of the following statements
concerning glucose metabolism is correct

A) Glucose enters most cells by a mechanism in which Na+ and glucose are co-transported

B) An elevated level of insulin leads to a decreased level of fructose 2, 6-bisphosphate in hepatocyte

C) The conversion of Glucose to lactate occurs only in the R.B.C

D) Pyruvate kinase catalyses an irreversible reaction

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5. Which one of the following would be
expected in pyruvate kinase deficiency

A) Decreased ratio of ADP to ATP in R.B.C

B) Increased levels of lactate in the R.B.C

C) Hemolytic anemia

D) Increased phosphorylation of Glucose to Glucose-6-phosphate

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6. Which of the following enzyme is not
involved in HMP shunt

A) Phosphogluconate dehydrogenase

B) Glyceraldehyde-3-p dehydrogenase

C) Transketolase

D) Glucose-6-p-dehydrogenase

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7. Phenylalanine is the precursor of

A) Tyrosine

B) L-DOPA

C) Throxine

D) Histamine

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8. An allosteric enzyme responsible for
controlling the rate of T.C.A cycle is

A) Aconitase

B) Fumarase

C) Isocitrate dehydrogenase

D) Malate dehydrogenase

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9. Cori cycle is

A) Both (A) & (B

B) Synthesis of glucose

C) uptake of glycose

D) reuse of glucose

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10. All of the following statements about the
enzymic complex that carries out the
synthesis of ATP during oxidative
phosphorylation are correct except

A) ) It can bind molecular O2

B) It can exhibit ATPase activity

C) It is inhibited by oligomycin

D) It is located on the matrix side of the inner mitochondrial membrane

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11. Out of 24 mols of ATP formed in TCA cycle,
2 molecules of ATP can be formed at
“substrate level” by which of the
following reaction

A) socitrate→ Oxaloacetate

B) Succinic acid→ Fumarate

C) Citric acid→ Isocitric acid

D) Succinylcat→ Succinic acid

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12. The reaction catalysed by phosphofructokinase

A) Uses fruitose-1-phosphate as substrate

B) Is the rate-limiting reaction of the glycolytic pathway

C) Is activated by high concentrations of ATP and citrate

D) Is inhibited by fructose 2, 6-bisphosphate

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13. The reaction catalysed by phosphofructokinase

A) Is inhibited by fructose 2, 6-bisphosphate

B) Uses fruitose-1-phosphate as substrate

C) Is the rate-limiting reaction of the glycolytic pathway

D) Is activated by high concentrations of ATP and citrate

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14. Compared to the resting state, vigorously
contracting muscle shows

A) Decreased oxidation of pyruvate of CO2 and water

B) Decreased concentration of AMP

C) An increased conversion of pyruvate to lactate

D) A decreased NADH/NAD+ ratio

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15. How many ATPs are produced in the
conversion of phosphoenol pyruvate to
citrate

A) 1

B) 4

C) 6

D) 2

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16. The glycolysis is regulated by

A) Phosphofructokinase

B) Hexokinase

C) All of these

D) Pyruvate kinase

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17. An uncoupler of oxidative phosphorylation such as dinitropheno

A) Inhibits electron transport and ATP synthesis

B) Inhibits electron transport without impairment of ATP synthesis

C) Allow electron transport to proceed without ATP synthesis

D) Specially inhibits cytochrome b

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18. The free energy change, AG

A) Is equal to zero at equilibrium

B) Is equal to –RT in keq

C) Is directly proportional to the standard free energy change, AG

D) Can only be calculated when the reactants and products are present at 1mol/1 concentrations

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19. The synthesis of glucose from pyruvate
by gluconeogenesis

A) Occurs exclusively in the cytosol

B) Requires oxidation/reduction of FAD

C) Requires the participation of biotin

D) Is inhibited by elevated level of insulin

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20. Phenylalanine is the precursor of

A) Histamine

B) Tyrosine

C) Throxine

D) L-DOPA

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21. Glycogen is present in all body tissues
except

A) Liver

B) Stomach

C) Kidney

D) Brain

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22. In presence of the following cofactor,
pyruvate carboxylase converts pyruvate
to oxaloacetate

A) Protein

B) CO2 and ATP

C) ATP, Protein and CO2

D) CO2

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23. Which of the following reactions is unique
to gluconeogenesis

A) Phosphoenol pyruvate pyruvate

B) Oxaloacetate phosphoenol pyruvate

C) Glucose-6-phosphate Fructose-6-phosphate

D) Lactate Pyruvate

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24. Electron transport and phosphorylation
can be uncoupled by compounds that
increase the permeability of the inner
mitochondrial membrane to

A) Protons

B) Electrons

C) All of these

D) Uncouplers

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25. Which of the following statements
regarding T.C.A cycle is true

A) It occurs in cytosol

B) It is amphibolic in nature

C) It is an anaerobic process

D) It contains no intermediates for GluconeogenesisIt contains no intermediates for Gluconeogenesis

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26. For conversion of oxaloacetate to
phosphoenol pyruvate, high energy
molecule is required in the form of

A) GTP (or) ITP

B) None of these

C) ITP only

D) GTP only

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27. The conversion of pyruvate to acetyl CoA
and CO2

A) Involves the participation of lipoic acid

B) Occurs in the cytosol

C) Is reversible

D) Depends on the coenzyme biotin

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28. Reduced glutathione functions in R.B.Cs
to

A) Reduce methemoglobin to hemoglobin

B) Produce NADPH

C) Produce NADH

D) Reduce oxidizing agents such as H2O2

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29. How many ATP molecules will be required
for conversion of 2-molecules of Lactic acid
to Glucose

A) 2

B) 8

C) 6

D) 4

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30. The more positive the E0, the greater the
tendency of the oxidant member of that
pair to

A) Lose electrons

B) Gain electrons

C) Lose and gain electrons

D) Lose (or) gain electrons

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31. Which one of the following compounds
cannot give rise to the net synthesis of
Glucose

A) Glycerol

B) Acetyl CoA

C) α-ketoglutarate

D) Lactate

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The average score is 40%

Carbohydrates Biochemistry Set 5

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