Carbohydrates Biochemistry Set 5

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Biochemistry (Carbohydrates And Carbohydrate Metabolism Set 5)

MCQ

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1. Which of the following enzyme is not
involved in HMP shunt

A) Transketolase

B) Glyceraldehyde-3-p dehydrogenase

C) Phosphogluconate dehydrogenase

D) Glucose-6-p-dehydrogenase

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2. The synthesis of glucose from pyruvate
by gluconeogenesis

A) Requires the participation of biotin

B) Occurs exclusively in the cytosol

C) Requires oxidation/reduction of FAD

D) Is inhibited by elevated level of insulin

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3. Which of the following reactions is unique
to gluconeogenesis

A) Lactate Pyruvate

B) Glucose-6-phosphate Fructose-6-phosphate

C) Phosphoenol pyruvate pyruvate

D) Oxaloacetate phosphoenol pyruvate

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4. Reduced glutathione functions in R.B.Cs
to

A) Reduce methemoglobin to hemoglobin

B) Produce NADPH

C) Reduce oxidizing agents such as H2O2

D) Produce NADH

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5. The glycolysis is regulated by

A) Pyruvate kinase

B) Phosphofructokinase

C) All of these

D) Hexokinase

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6. All of the following statements about the
enzymic complex that carries out the
synthesis of ATP during oxidative
phosphorylation are correct except

A) ) It can bind molecular O2

B) It is located on the matrix side of the inner mitochondrial membrane

C) It can exhibit ATPase activity

D) It is inhibited by oligomycin

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7. Which of the following statements
regarding T.C.A cycle is true

A) It occurs in cytosol

B) It is amphibolic in nature

C) It is an anaerobic process

D) It contains no intermediates for GluconeogenesisIt contains no intermediates for Gluconeogenesis

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8. The reaction catalysed by phosphofructokinase

A) Uses fruitose-1-phosphate as substrate

B) Is the rate-limiting reaction of the glycolytic pathway

C) Is activated by high concentrations of ATP and citrate

D) Is inhibited by fructose 2, 6-bisphosphate

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9. Cori cycle is

A) uptake of glycose

B) Synthesis of glucose

C) reuse of glucose

D) Both (A) & (B

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10. Phenylalanine is the precursor of

A) Histamine

B) Throxine

C) Tyrosine

D) L-DOPA

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11. Phenylalanine is the precursor of

A) Throxine

B) Histamine

C) L-DOPA

D) Tyrosine

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12. Which one of the following compounds
cannot give rise to the net synthesis of
Glucose

A) Acetyl CoA

B) α-ketoglutarate

C) Lactate

D) Glycerol

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13. How many ATPs are produced in the
conversion of phosphoenol pyruvate to
citrate

A) 2

B) 4

C) 6

D) 1

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14. Under standard conditions

A) The free energy change, ∆G°, is equal to the standard free energy change, ∆G°

B) The standard free energy change ∆G, is equal to 0

C) The free energy change ∆G°, is equal to 0

D) Keq is equal to 1

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15. The more positive the E0, the greater the
tendency of the oxidant member of that
pair to

A) Lose (or) gain electrons

B) Lose electrons

C) Gain electrons

D) Lose and gain electrons

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16. Out of 24 mols of ATP formed in TCA cycle,
2 molecules of ATP can be formed at
“substrate level” by which of the
following reaction

A) Citric acid→ Isocitric acid

B) Succinic acid→ Fumarate

C) Succinylcat→ Succinic acid

D) socitrate→ Oxaloacetate

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17. Which one of the following would be
expected in pyruvate kinase deficiency

A) Increased phosphorylation of Glucose to Glucose-6-phosphate

B) Decreased ratio of ADP to ATP in R.B.C

C) Hemolytic anemia

D) Increased levels of lactate in the R.B.C

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18. The reaction catalysed by phosphofructokinase

A) Is activated by high concentrations of ATP and citrate

B) Uses fruitose-1-phosphate as substrate

C) Is inhibited by fructose 2, 6-bisphosphate

D) Is the rate-limiting reaction of the glycolytic pathway

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19. How many ATP molecules will be required
for conversion of 2-molecules of Lactic acid
to Glucose

A) 2

B) 4

C) 8

D) 6

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20. An allosteric enzyme responsible for
controlling the rate of T.C.A cycle is

A) Malate dehydrogenase

B) Isocitrate dehydrogenase

C) Aconitase

D) Fumarase

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21. An uncoupler of oxidative phosphorylation such as dinitropheno

A) Allow electron transport to proceed without ATP synthesis

B) Inhibits electron transport and ATP synthesis

C) Inhibits electron transport without impairment of ATP synthesis

D) Specially inhibits cytochrome b

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22. Glycogen is present in all body tissues
except

A) Liver

B) Brain

C) Kidney

D) Stomach

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23. The conversion of pyruvate to acetyl CoA
and CO2

A) Is reversible

B) Depends on the coenzyme biotin

C) Involves the participation of lipoic acid

D) Occurs in the cytosol

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24. For conversion of oxaloacetate to
phosphoenol pyruvate, high energy
molecule is required in the form of

A) GTP (or) ITP

B) None of these

C) GTP only

D) ITP only

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25. Electron transport and phosphorylation
can be uncoupled by compounds that
increase the permeability of the inner
mitochondrial membrane to

A) All of these

B) Uncouplers

C) Electrons

D) Protons

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26. Reduced glutathione functions in R.B.Cs
to

A) Produce NADPH

B) Reduce oxidizing agents such as H2O2

C) Produce NADH

D) Reduce methemoglobin to hemoglobin

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27. Glucokinase

A) None of these

B) Is widely distributed in Prokaryotes

C) Has a high km for glucose and hence is important in the phosphorylation of glucose primarily after ingestion of a carbohydrate rich meal

D) Is widely distributed and occurs in most mammalian tissues

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28. Which one of the following statements
concerning glucose metabolism is correct

A) Glucose enters most cells by a mechanism in which Na+ and glucose are co-transported

B) The conversion of Glucose to lactate occurs only in the R.B.C

C) An elevated level of insulin leads to a decreased level of fructose 2, 6-bisphosphate in hepatocyte

D) Pyruvate kinase catalyses an irreversible reaction

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29. In presence of the following cofactor,
pyruvate carboxylase converts pyruvate
to oxaloacetate

A) Protein

B) ATP, Protein and CO2

C) CO2

D) CO2 and ATP

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30. Compared to the resting state, vigorously
contracting muscle shows

A) A decreased NADH/NAD+ ratio

B) Decreased oxidation of pyruvate of CO2 and water

C) An increased conversion of pyruvate to lactate

D) Decreased concentration of AMP

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31. The free energy change, AG

A) Is equal to –RT in keq

B) Can only be calculated when the reactants and products are present at 1mol/1 concentrations

C) Is equal to zero at equilibrium

D) Is directly proportional to the standard free energy change, AG

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The average score is 58%

Carbohydrates Biochemistry Set 5

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