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Limb Development — Musculoskeletal & Limb Development
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Limb Development
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Limb Development MCQs: practice questions
Sample Limb Development multiple-choice questions from Musculoskeletal & Limb Development.
What is the main developmental effect of FGF from the apical ectodermal ridge?
- A. Causes medial limb rotation
- B. Forms the umbilical vessels
- C. Promotes limb outgrowth
- D. Induces neural crest migration
- E. Directly forms bone
Which teratogen is associated with amelia?
- A. Ethanol
- B. Warfarin
- C. Thalidomide
- D. Lead
- E. Methotrexate
Which tissue forms the central skeletal axis of the developing limb?
- A. Endoderm
- B. Neural tube
- C. Surface ectoderm
- D. Lateral plate mesoderm
- E. Somitic mesoderm
During which week does the hyaline cartilage model of the limb bones form?
- A. Week 8
- B. Week 12
- C. Week 4
- D. Week 6
- E. Week 5
Where is the zone of polarizing activity located?
- A. Inside the somites
- B. At the distal umbilical cord
- C. At the base of the limb bud
- D. Within the neural tube
- E. At the tip of the limb bud
Which congenital anomaly involves extra digits?
Which congenital anomaly is defined by complete absence of a limb?
Which additional signaling molecule has an important role in limb polarization?
At what developmental time do the limb buds first become visible?
Which embryonic tissue forms the musculature of the limbs?
How are the five digits separated during limb development?
Which structure at the limb tip exerts an inductive influence on limb growth?
During which week does limb-bud mesoderm condense before cartilage formation?
Which signaling molecule is produced by the zone of polarizing activity?
Which congenital anomaly involves fusion of adjacent digits?
Which gene expressed by the apical ectodermal ridge organizes the limb along the dorsal-ventral axis?
Which limb abnormality is associated with failure of the hand or foot webs to degenerate?
Which limb patterning center is primarily responsible for anterior-posterior organization?
Which embryonic tissue forms the skeletal and vascular components of the limb bud?
Which upper-limb abnormality is associated with heart defects in Holt-Oram syndrome?
Which congenital anomaly is characterized by partial absence of a limb?
During which developmental interval do the limbs become well differentiated?
What is the apical ectodermal ridge?
Which limb bud appears first?
Which chromosome is associated with Holt-Oram syndrome in the source?
Which genes are activated by sonic hedgehog during limb development?
Which signaling factors are implicated in digit formation?
Which signaling molecule is produced by the apical ectodermal ridge to promote limb outgrowth?
What developmental process converts the condensed limb mesoderm into a cartilage model?
What is the major role of sonic hedgehog in limb development?