CNS Infections & Demyelinating Diseases — CNS & Musculoskeletal

CNS Infections & Demyelinating Diseases MCQs: practice questions

Sample CNS Infections & Demyelinating Diseases multiple-choice questions from CNS & Musculoskeletal.

1. What is the most common portal of entry for CNS infection?

   • A. Lymphatic spread
   • B. Hematogenous spread
   • C. Transplacental spread in all cases
   • D. Direct bone spread
   • E. Urinary spread

2. Which complication can follow fibroblastic arachnoiditis?

   • A. Parkinson disease
   • B. Huntington disease
   • C. Hydrocephalus
   • D. Osteosarcoma
   • E. Osteoporosis

3. Which clinical course is characteristic of multiple sclerosis?

   • A. Constant progression from birth
   • B. Exacerbations with long asymptomatic remissions
   • C. Acute coma in every case
   • D. Single episode with no recurrence
   • E. Only peripheral relapses

4. What defines a demyelinating disease?

   • A. Hemorrhage into ventricles
   • B. Destruction of myelin with relative preservation of axons
   • C. Destruction of bone
   • D. Loss of all peripheral nerves
   • E. Primary neuronal loss only

5. Which triad may occur in multiple sclerosis?

   • A. Chorea, athetosis, and wasting
   • B. Fever, headache, and nuchal rigidity
   • C. Resting tremor, rigidity, and masked facies
   • D. Confusion, ataxia, and ophthalmoplegia
   • E. Nystagmus, intention tremor, and scanning speech

6. Which later change can occur in multiple sclerosis plaques?

7. PML is particularly associated with which condition?

8. Which infection causes rapidly progressive multifocal brain demyelination?

9. Which CSF finding supports multiple sclerosis?

10. What age range is typical for onset of multiple sclerosis?

11. How can meningitis cause hydrocephalus?

12. Which infection preferentially infects oligodendrocytes and causes demyelination?

13. Which statement distinguishes MS from Guillain-Barré syndrome?

14. Which disorder often follows measles, mumps, rubella, or chickenpox?

15. Which organism is frequent in neonatal and infant pyogenic meningitis?

16. Which can be an early manifestation of MS?

17. Which virus most often causes PML?

18. Which sex is more commonly affected by multiple sclerosis?

19. Which organism is a frequent cause of meningitis in older infants, children, and young adults?

20. Which CSF pattern is typical of pyogenic meningitis?

21. Which sites are favored for MS plaques?

22. Which demyelinating disease primarily involves peripheral nerves?

23. Which statement about CNS lymphatics is given?

24. Which CSF finding is characteristic of Guillain-Barré syndrome?

25. Which complication can result from pyogenic meningitis?

26. Which clinical finding is typical of pyogenic meningitis?

27. What is the major pathologic feature of ADEM?

28. Which cells produce CNS myelin and are depleted in MS plaques?

29. Which cells infiltrate MS plaques?

30. Which is the most common demyelinating disease?