Carcinogenesis — Neoplasia

Carcinogenesis MCQs: practice questions

Sample Carcinogenesis multiple-choice questions from Neoplasia.

1. Chemical carcinogens often require metabolic activation to form:

   • A. Antibodies
   • B. Structural collagen
   • C. Normal hormones
   • D. Inert proteins
   • E. Reactive electrophilic intermediates

2. Hepatitis B and C infections increase the risk of:

   • A. Thyroid lymphoma only
   • B. Osteosarcoma
   • C. Meningioma
   • D. Glioblastoma
   • E. Hepatocellular carcinoma

3. The most important defining feature of a malignant neoplasm is its ability to:

   • A. Remain encapsulated
   • B. Maintain normal tissue architecture
   • C. Stop dividing permanently
   • D. Invade locally and metastasize
   • E. Produce only benign hormones

4. The normal cellular counterpart of an oncogene is called a:

   • A. Proto-oncogene
   • B. Metastatic gene
   • C. Tumor suppressor
   • D. Housekeeping mutation
   • E. Caretaker gene

5. EBV contributes to oncogenesis partly through infection of:

   • A. B lymphocytes
   • B. Osteoclasts
   • C. Hepatocytes only
   • D. Erythrocytes
   • E. Neutrophils

6. Mismatch repair defects are associated with:

7. Lynch syndrome is caused by inherited defects in:

8. RAS proteins function primarily as:

9. The hallmark viral protein responsible for HPV-mediated inactivation of p53 is:

10. HPV E7 promotes cell proliferation primarily by inactivating:

11. Benzene exposure is associated with increased risk of:

12. A tumor suppressor gene normally functions to:

13. Helicobacter pylori infection is associated with gastric carcinoma and:

14. Loss of function of tumor suppressor genes generally requires:

15. An oncogene is best defined as a gene that:

16. Familial adenomatous polyposis is caused by germline mutation of:

17. The RB protein primarily regulates progression through the:

18. Tumor cells can evade immune destruction by:

19. The APC protein is important in regulation of the:

20. Ionizing radiation increases the risk of:

21. Aflatoxin exposure is strongly associated with:

22. The tumor suppressor p53 is important because it can:

23. High-risk HPV types most strongly associated with cervical cancer include:

24. Smoking is a major risk factor for:

25. BRCA1 and BRCA2 are important in:

26. Telomerase activation contributes to cancer by:

27. Chronic inflammation promotes cancer partly through:

28. A carcinogen that directly damages DNA is classified as a:

29. Asbestos exposure is strongly associated with:

30. Cancer-associated angiogenesis is promoted by: