Hormone Physiology — Endocrine & Metabolic Physiology

Hormone Physiology MCQs: practice questions

Sample Hormone Physiology multiple-choice questions from Endocrine & Metabolic Physiology.

1. Which hormone acts through an IP3-Ca2+ mechanism?

   • A. PTH
   • B. Glucocorticoid
   • C. Thyroid hormone
   • D. Insulin
   • E. Angiotensin II

2. Activation of a Gi protein causes:

   • A. Decreased adenylyl cyclase activity
   • B. Increased cAMP
   • C. Activation of receptor tyrosine kinase
   • D. Increased IP3 only
   • E. Direct activation of DNA polymerase

3. Which hormone uses a receptor tyrosine kinase?

   • A. Cortisol
   • B. Insulin
   • C. Aldosterone
   • D. Thyroid hormone
   • E. PTH

4. Positive feedback occurs when:

   • A. The response inhibits hormone release
   • B. The response reinforces the original stimulus
   • C. The target organ blocks all receptors
   • D. Hormone levels remain constant
   • E. A hormone is metabolized rapidly

5. The half-life of a steroid hormone is generally longer than that of a peptide hormone because steroids:

   • A. Bind plasma proteins
   • B. Are stored in secretory vesicles
   • C. Are rapidly degraded in plasma
   • D. Cannot enter cells
   • E. Are always water soluble

6. Slower but longer-lasting hormone effects are typical of hormones that:

7. Hormone synergism occurs when:

8. A receptor that activates transcription most directly is most likely located:

9. Negative feedback occurs when:

10. The receptor for a water-soluble hormone is usually:

11. Hormone Physiology 30 questions • Five related options • One best answer • Explanation 1. A peptide hormone is most likely to bind to a receptor located:

12. Permissiveness occurs when:

13. A hormone that activates phospholipase C will increase:

14. The biologically active fraction of a circulating hormone is usually the:

15. The IP3 pathway increases cytosolic Ca2+ by promoting Ca2+ release from the:

16. Growth hormone acts through a receptor associated with:

17. Down-regulation means that a target cell:

18. Peptide hormones are generally stored in:

19. Activation of a Gs protein causes:

20. ANP produces its effects primarily through:

21. If a target cell loses its receptor for a hormone, the most immediate consequence is:

22. A steroid hormone usually produces its cellular effect by:

23. Up-regulation of receptors causes:

24. Thyroid hormone acts most like a steroid hormone because it:

25. Which hormone is an amine but uses an intracellular receptor mechanism?

26. The cAMP second-messenger system is activated when a hormone receptor stimulates:

27. Steroid hormones are generally:

28. A hormone that binds to plasma proteins is expected to have:

29. Rapid effects of peptide hormones are often due to:

30. Most peptide hormones are synthesized initially as: