Inflammation & Healing/Repair — General

Inflammation & Healing/Repair MCQs: practice questions

Sample Inflammation & Healing/Repair multiple-choice questions from General.

1. Which chemical mediator is a potent chemotactic factor produced through the lipoxygenase pathway?

   • A. Prostaglandin E2
   • B. Thromboxane A2
   • C. Histamine
   • D. Leukotriene B4
   • E. Bradykinin

2. Which complement fragment is primarily responsible for opsonization of bacteria, enhancing phagocytosis?

   • A. C5a
   • B. C3a
   • C. C9
   • D. C1q alone
   • E. C3b

3. A wound infection significantly impairs healing primarily by prolonging which phase of the repair process?

   • A. The proliferative phase, with minimal effect on inflammation
   • B. The remodeling phase
   • C. Prolongs the inflammatory phase
   • D. Infection has no relevant effect on wound healing phases
   • E. The hemostasis phase

4. Which cell type is most associated with chronic inflammation driven by parasitic infections or allergic reactions?

   • A. Eosinophils
   • B. Neutrophils
   • C. Basophils
   • D. Platelets
   • E. Red blood cells

5. C5a and C3a are best described functionally as which type of mediator?

   • A. Direct bactericidal proteins
   • B. Structural components of the membrane attack complex
   • C. Mast-cell-triggering anaphylatoxins
   • D. Direct opsonins with no other function
   • E. Coagulation factors

6. Which cytokine is a major mediator of fever during systemic inflammation?

7. Wound healing by first (primary) intention is most appropriate for which type of wound?

8. Bradykinin, generated through the kinin system, produces which effect during inflammation?

9. PECAM-1 (CD31) plays its primary role in which step of leukocyte migration?

10. Integrins on leukocytes are primarily responsible for which step of the extravasation process?

11. Neurons and cardiac myocytes are classified as which type of tissue regarding regenerative capacity?

12. The cardinal signs of acute inflammation (redness, heat, swelling, pain) result primarily from which vascular change?

13. Vitamin C deficiency impairs wound healing primarily through which mechanism?

14. Labile cells, such as those in the gut epithelium and bone marrow, are characterized by which regenerative property?

15. Contact inhibition, relevant to epithelial regeneration during healing, describes which cellular behavior?

16. Which collagen type predominates in early granulation tissue, later being replaced by a stronger type in mature scar?

17. Selectins mediate which step of leukocyte extravasation?

18. TGF-beta plays which key role in the later stages of wound healing?

19. Granulation tissue is histologically characterized by which combination of features?

20. Wound tensile strength at one week post-injury is typically what proportion of unwounded skin's strength?

21. The membrane attack complex (C5b-9) causes cell death primarily through which mechanism?

22. Which growth factor is particularly important in stimulating angiogenesis during wound healing?

23. Chronic inflammation differs from acute inflammation in its predominant cellular infiltrate, consisting mainly of which cells?

24. Which factor most directly explains why diabetic patients often have impaired wound healing?

25. Margination of neutrophils during acute inflammation refers to which process?

26. Prostaglandins produced during inflammation are generated through which enzymatic pathway?

27. A foreign body giant cell forms through which process?

28. Keloid formation results from which underlying process?

29. Myofibroblasts, present in granulation tissue, are primarily responsible for which aspect of wound healing?

30. Dehiscence, a serious complication of wound healing, refers to which event?