Drugs for Gout & Rheumatic Inflammation — Analgesics, Anesthesia & Inflammation

Drugs for Gout & Rheumatic Inflammation MCQs: practice questions

Sample Drugs for Gout & Rheumatic Inflammation multiple-choice questions from Analgesics, Anesthesia & Inflammation.

1. Which agent is a uricosuric drug used in chronic gout?

   • A. Febuxostat
   • B. Sulfinpyrazone
   • C. Allopurinol
   • D. Colchicine
   • E. Indomethacin

2. Which treatment is preferred for an acute gout attack?

   • A. Nonsalicylate NSAIDs
   • B. Allopurinol alone
   • C. Probenecid alone
   • D. Febuxostat alone
   • E. Methotrexate alone

3. What is the principal limitation of NSAIDs in chronic rheumatic disease?

   • A. They cannot reduce pain
   • B. They cannot reduce inflammation
   • C. They always cause hepatotoxicity
   • D. They eliminate all autoantibodies
   • E. They do not significantly reverse disease progression

4. Why is colchicine often administered when allopurinol is initiated?

   • A. To increase xanthine oxidase activity
   • B. To increase uric acid production
   • C. To inhibit renal urate secretion
   • D. To prevent allopurinol absorption
   • E. To reduce precipitation of an acute gout attack

5. Which adverse effect can result from increased urinary uric acid during uricosuric therapy?

   • A. Hypoglycemia
   • B. Respiratory depression
   • C. Urolithiasis
   • D. Hypercalcemia
   • E. Severe bradycardia

6. Which gold compound is administered orally?

7. Which agent reduces T-cell activation by competing with CD28 for CD80 and CD86?

8. How soon after oral colchicine does reduction in inflammation and pain generally occur?

9. Which drug is used for rheumatoid arthritis when NSAIDs or glucocorticoids are inadequate?

10. What is the principal cellular action of colchicine?

11. Which drug targets α4-integrin and is used in multiple sclerosis and Crohn disease?

12. Which drug increases uric acid excretion by reducing tubular uric acid reabsorption?

13. Which drugs inhibit xanthine oxidase?

14. For which purpose are allopurinol and febuxostat used?

15. Which agent is a recombinant uricase used for serious gout refractory to other therapy?

16. Which class is first-line symptomatic therapy for many rheumatic inflammatory diseases?

17. Which monoclonal antibody targets the IL-6 receptor?

18. Which statement best distinguishes acute from chronic gout treatment?

19. Which drug can chelate gold and has immunosuppressive activity of uncertain mechanism?

20. Which drug's renal excretion is inhibited by probenecid?

21. Which drug is an alkaloid used to relieve inflammation and pain in acute gout?

22. How can the risk of urate stones during probenecid therapy be reduced?

23. Which adverse effect commonly limits methotrexate therapy?

24. Which drug is contraindicated in gout because low doses inhibit uric acid secretion?

25. Which adverse effect can occur with gold therapy?

26. Which monoclonal antibody targets CD20 on B lymphocytes in rheumatoid arthritis?

27. Which antimalarial is used for joint pain associated with lupus and arthritis?

28. What is a major concern with intravenous colchicine?

29. Which drug should not be started as sole treatment of an acute gout attack?

30. Which adverse effect is particularly common with oral colchicine?