Local Anesthetics — Analgesics, Anesthesia & Inflammation

Local Anesthetics MCQs: practice questions

Sample Local Anesthetics multiple-choice questions from Analgesics, Anesthesia & Inflammation.

1. Which local anesthetic has a medium onset and short duration and is used for infiltration anesthesia?

   • A. Bupivacaine
   • B. Tetracaine
   • C. Procaine
   • D. Lidocaine
   • E. Cocaine

2. What most commonly causes systemic local-anesthetic toxicity?

   • A. Overdose or inadvertent intravascular injection
   • B. Low tissue blood flow only
   • C. Topical use at recommended dose
   • D. Renal filtration
   • E. Low lipid solubility

3. Which cardiovascular effect can occur during systemic local-anesthetic toxicity?

   • A. Persistent sinus tachycardia
   • B. Marked hypertension
   • C. Bradycardia
   • D. Increased cardiac contractility
   • E. Severe hypernatremia

4. Which local anesthetic produces less drowsiness and sedation than lidocaine?

   • A. Procaine
   • B. Cocaine
   • C. Mepivacaine
   • D. Tetracaine
   • E. Bupivacaine

5. Which nerve fibers are generally blocked first by local anesthetics?

   • A. Large myelinated Aα fibers
   • B. Large motor fibers
   • C. Small nonmyelinated C fibers
   • D. Proprioceptive fibers only
   • E. All fibers equally

6. Which local anesthetic is the prototype amide with rapid onset and intermediate duration?

7. What is the primary molecular target of local anesthetics?

8. Which local anesthetic is used for infiltration, peripheral nerve block, epidural, and spinal anesthesia?

9. Which class is metabolized mainly by hepatic microsomal enzymes?

10. Which condition can reduce clearance of amide local anesthetics?

11. Which local anesthetic has a slow onset, long duration, and greater cardiotoxicity than other amide agents?

12. Which local anesthetic is primarily used for spinal and ophthalmologic anesthesia and has a very slow onset?

13. Why can local anesthetics be less effective in inflamed tissue?

14. How does lipid solubility affect local-anesthetic potency?

15. Which metabolite of procaine can limit sulfonamide effectiveness?

16. Which local anesthetic has a very slow onset of more than 10 minutes?

17. Why can cocaine be useful for topical anesthesia of mucous membranes?

18. Which class of local anesthetics is metabolized primarily by plasma butyrylcholinesterase?

19. Which local anesthetic is associated with greater cardiotoxicity than other amide agents?

20. Which local anesthetic can cause methemoglobinemia through a metabolite?

21. Which local anesthetic is useful for spinal anesthesia and has vasoconstrictor activity?

22. Which local anesthetic has medium onset and medium duration and is used rarely for topical mucosal anesthesia?

23. Which sodium-channel state is preferentially bound by the charged form of a local anesthetic?

24. Which ester local anesthetic is rapidly metabolized by plasma cholinesterase and used in obstetrical anesthesia?

25. Which statement about local anesthetics is correct?

26. Which CNS effect can occur at high local-anesthetic blood concentrations?

27. What causes hypotension during systemic local-anesthetic toxicity?

28. Which local anesthetic produces intense vasoconstriction?

29. Why are pain and temperature sensations lost before motor function during local anesthesia?

30. How are seizures from systemic local-anesthetic toxicity treated?