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Antifungal Drugs — Antimicrobial Pharmacology II
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Antifungal Drugs
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Antifungal Drugs MCQs: practice questions
Sample Antifungal Drugs multiple-choice questions from Antimicrobial Pharmacology II.
Which electrolyte abnormality can occur with amphotericin B nephrotoxicity?
- A. Hypokalemia
- B. Hyperkalemia
- C. Hypercalcemia
- D. Hypernatremia
- E. Hyperphosphatemia
Which fungal membrane component is bound by amphotericin B?
- A. Ergosterol
- B. Cholesterol only
- C. Peptidoglycan
- D. Mycolic acid
- E. PABA
Which enzyme is inhibited by azole antifungals?
- A. DNA gyrase
- B. Dihydropteroate synthase
- C. 14α-Demethylase
- D. RNA polymerase
- E. Transpeptidase
Which toxicity is associated with flucytosine?
- A. Bone marrow suppression
- B. Red man syndrome
- C. Tendon rupture
- D. Optic neuritis
- E. Severe ototoxicity
Which antifungal class targets fungal cell-wall synthesis rather than the fungal membrane?
- A. Polyenes
- B. Azoles
- C. Allylamines
- D. Echinocandins
- E. Macrolides
Which antifungal can be given intrathecally for refractory CNS infection?
Which antifungal has the broadest spectrum of activity?
Why are bacteria not susceptible to amphotericin B?
Which antifungal class inhibits fungal cytochrome P450-dependent ergosterol synthesis?
Which antifungal is particularly effective against Candida species?
Which serious toxicity is associated with amphotericin B?
Which antifungal can cause endocrine adverse effects because it inhibits steroid synthesis?
What is the principal membrane effect of amphotericin B?
Which adverse effect can occur with systemic ketoconazole?
Which antifungal is useful for dermatophyte infections by interfering with microtubule function?
Which antifungal produces membrane disruption rather than inhibition of ergosterol synthesis?
Which fungal membrane target is analogous in importance to cholesterol in mammalian membranes?
Which antifungal is a polyene that binds ergosterol?
Which antifungal is associated with bone marrow suppression because it is an antimetabolite?
Which antifungal class blocks synthesis of β-(1,3)-D-glucan?
Which antifungal is used for blastomycosis and paracoccidioidomycosis?
Which antifungal is poorly absorbed orally and therefore is mainly used IV for systemic disease?
Which antifungal is commonly combined with amphotericin B for Cryptococcus neoformans?
Which route is commonly used for systemic amphotericin B therapy?
Which antifungal is most directly associated with ergosterol binding rather than enzyme inhibition?
Which antifungal inhibits squalene epoxidase and is used for dermatophyte infections?
Which antifungal class inhibits ergosterol synthesis?
Which fungal infection is treated with amphotericin B plus flucytosine?
Which antifungal inhibits fungal DNA and RNA synthesis after conversion to 5-fluorouracil?
Which enzyme converts flucytosine to its active metabolite?