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Antiplatelet & Thrombolytic Drugs — Hematology & GI Pharmacology

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Antiplatelet & Thrombolytic Drugs
Hematology & GI Pharmacology · Antiplatelet & Thrombolytic Drugs · medium
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Antiplatelet & Thrombolytic Drugs MCQs: practice questions

Sample Antiplatelet & Thrombolytic Drugs multiple-choice questions from Hematology & GI Pharmacology.

  1. Which antiplatelet drug irreversibly inhibits platelet cyclooxygenase and decreases thromboxane A2 production?

    • A. Warfarin
    • B. Aspirin
    • C. Dipyridamole
    • D. Heparin
    • E. Alteplase
  2. Which thrombolytic is a recombinant fragment of human tPA?

    • A. Streptokinase
    • B. Urokinase
    • C. Reteplase
    • D. Heparin
    • E. Warfarin
  3. Which thrombolytic acts on both circulating plasminogen and fibrin-bound plasminogen?

    • A. Warfarin
    • B. Reteplase
    • C. Alteplase
    • D. Tenecteplase
    • E. Streptokinase
  4. Which agent prevents fibrinogen-mediated platelet aggregation by blocking the final common platelet aggregation receptor?

    • A. Abciximab
    • B. Alteplase
    • C. Vitamin K
    • D. Warfarin
    • E. Heparin
  5. Which drug inhibits platelet aggregation rather than directly dissolving an existing fibrin clot?

    • A. Clopidogrel
    • B. Reteplase
    • C. Alteplase
    • D. Streptokinase
    • E. Urokinase
  6. Which adverse effect is especially important when GPIIb/IIIa inhibitors are combined with heparin?

  7. Which agent is used to reduce platelet aggregation by inhibiting ADP-mediated activation?

  8. What is the principal adverse effect of GPIIb/IIIa inhibitors?

  9. Which P2Y12 inhibitor has the same mechanism as ticlopidine but fewer adverse effects and a very low frequency of neutropenia?

  10. Which drug is used during percutaneous coronary intervention and is administered by infusion as a GPIIb/IIIa inhibitor?

  11. Which thrombolytic is a bacterial protein that activates plasminogen nonenzymatically?

  12. Which enzyme directly degrades fibrin in the fibrinolytic pathway?

  13. Which platelet receptor is directly targeted by abciximab?

  14. Which thrombolytic has a half-life long enough to permit bolus administration?

  15. Which adverse effect is common to all thrombolytic drugs?

  16. Which thrombolytic is derived from streptococci?

  17. Which drug is a direct platelet inhibitor rather than an anticoagulant?

  18. Which antiplatelet drug is a platelet COX inhibitor?

  19. Which drug is a chimeric monoclonal antibody fragment?

  20. Which treatment most directly promotes fibrin clot dissolution?

  21. Which thrombolytics are engineered forms of human tPA with longer half-lives?

  22. Which thrombolytic is most specific for fibrin-bound plasminogen?

  23. Which GPIIb/IIIa inhibitor is a small synthetic peptide?

  24. Which antiplatelet class blocks the platelet ADP P2Y12 receptor?

  25. Which thrombolytic is recombinant human tissue plasminogen activator?

  26. Which drug is a peptide mimetic that binds platelet GPIIb/IIIa?

  27. Which antithrombotic agent impairs fibrin polymerization and platelet function in vivo by an unclear mechanism?

  28. Which drug is a GPIIb/IIIa inhibitor?

  29. What is the immediate precursor activated by thrombolytic therapy to generate plasmin?

  30. Which thrombolytic is produced in the kidney and activates plasminogen?

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