Blood Transfusion, Hemostasis & Surgical Bleeding — General Surgery

Blood Transfusion, Hemostasis & Surgical Bleeding MCQs: practice questions

Sample Blood Transfusion, Hemostasis & Surgical Bleeding multiple-choice questions from General Surgery.

1. Which mechanism causes acute hemolytic transfusion reactions from ABO incompatibility?

   • A. Cryoprecipitate
   • B. Preformed recipient IgM antibodies activate complement
   • C. Prothrombin time
   • D. Heparin-induced thrombocytopenia
   • E. Petechiae, epistaxis, and mucosal bleeding

2. Which complication is associated with massive transfusion?

   • A. Anamnestic antibody response to a previously encountered red-cell antigen
   • B. Platelets
   • C. Petechiae, epistaxis, and mucosal bleeding
   • D. Factor VIII or IX deficiency affects the intrinsic pathway
   • E. Hypocalcemia from citrate

3. Which platelet receptor binds fibrinogen during platelet aggregation?

   • A. Acute hemolytic transfusion reaction
   • B. GPIIb/IIIa
   • C. Platelet adhesion and primary plug formation
   • D. Platelets and clotting factors become relatively depleted
   • E. Packed red blood cells

4. A patient develops diffuse bleeding, thrombocytopenia, prolonged PT and aPTT, and elevated fibrin degradation products. The diagnosis is

   • A. Preformed recipient IgM antibodies activate complement
   • B. GPIIb/IIIa
   • C. Disseminated intravascular coagulation
   • D. Hemophilia A
   • E. Vitamin K

5. Which mechanism causes HIT type II?

   • A. Antibodies against PF4-heparin complexes
   • B. Cryoprecipitate
   • C. Factor VIII or IX deficiency affects the intrinsic pathway
   • D. Hypocalcemia from citrate
   • E. Schistocytes

6. A patient has severe thrombocytopenia and thrombosis several days after heparin exposure. The likely diagnosis is

7. Which clinical pattern most strongly suggests a platelet disorder?

8. Which finding most strongly suggests a coagulation factor disorder?

9. Which blood product is most appropriate for significant thrombocytopenia with active bleeding?

10. Which blood product primarily replaces oxygen-carrying capacity?

11. Which product contains fibrinogen and factor VIII and may be used when fibrinogen is critically low?

12. A patient develops fever and chills during a transfusion but has no evidence of hemolysis. The likely reaction is

13. Massive transfusion can also cause

14. Which hemostatic defect causes deep tissue and joint bleeding?

15. Which vitamin is required for hepatic γ-carboxylation of factors II, VII, IX, and X?

16. Which laboratory test evaluates the extrinsic and common coagulation pathways?

17. Which laboratory test evaluates the intrinsic and common pathways?

18. Which medication irreversibly inhibits platelet cyclooxygenase?

19. Which plasma protein mediates platelet adhesion to exposed subendothelium?

20. Which red cell finding is characteristic of DIC?

21. A patient has mucosal bleeding, prolonged bleeding time, and a prolonged PTT due to reduced factor VIII stabilization. The likely disorder is

22. A patient with hemophilia develops prolonged aPTT but normal PT. Why?

23. A patient develops flank pain, fever, hypotension, and hemoglobinuria shortly after an incompatible transfusion. This is

24. A patient with severe liver disease has prolonged PT and aPTT. The mechanism is

25. Which hemostatic process occurs first after vascular injury?

26. Which inherited disorder is caused by factor IX deficiency?

27. Which blood product is used to replace multiple coagulation factors?

28. A delayed hemolytic transfusion reaction is usually caused by

29. Why can massive transfusion cause dilutional coagulopathy?

30. Which inherited disorder is caused by factor VIII deficiency?