Anemias — Hematopathology

Anemias MCQs: practice questions

Sample Anemias multiple-choice questions from Hematopathology.

1. Which finding favors iron deficiency anemia over anemia of chronic disease?

   • A. High ferritin
   • B. High serum iron
   • C. Low total iron-binding capacity
   • D. High hepcidin
   • E. Low ferritin

2. Autoimmune hemolytic anemia caused by warm IgG antibodies typically shows:

   • A. Iron deficiency
   • B. Only intravascular hemolysis
   • C. Platelet aggregation
   • D. Marrow aplasia
   • E. Extravascular hemolysis

3. A positive direct antiglobulin test supports the diagnosis of:

   • A. Aplastic anemia
   • B. Iron deficiency anemia
   • C. Immune-mediated hemolytic anemia
   • D. Thalassemia trait only
   • E. Pure red cell aplasia only

4. Cold agglutinin disease is usually mediated by:

   • A. IgE only
   • B. IgM antibodies
   • C. IgG only
   • D. IgD only
   • E. IgA only

5. A peripheral smear in thalassemia commonly shows:

   • A. Auer rods
   • B. Spherocytes only
   • C. Target cells
   • D. Giant platelets only
   • E. Smudge cells only

6. Anemia of chronic inflammation is mediated in part by increased:

7. Aplastic anemia may be caused by:

8. Aplastic anemia is characterized by:

9. The peripheral smear in megaloblastic anemia commonly shows:

10. The hemoglobin abnormality in sickle cell disease is:

11. G6PD deficiency predisposes to hemolysis after exposure to:

12. Sickle cell disease results from a mutation affecting:

13. Folate deficiency differs from vitamin B12 deficiency because folate deficiency:

14. Hereditary spherocytosis is most commonly due to defects in:

15. Pernicious anemia results from autoimmune destruction of:

16. A peripheral smear during acute G6PD-related hemolysis may show:

17. Iron deficiency anemia typically produces red cells that are:

18. A classic cause of folate deficiency is:

19. A low haptoglobin level is particularly suggestive of:

20. In anemia of chronic inflammation, serum ferritin is usually:

21. A deficiency of vitamin B12 can cause:

22. The most characteristic laboratory finding in iron deficiency anemia is:

23. Thalassemia is characterized by:

24. Hereditary spherocytosis typically produces:

25. Megaloblastic anemia is characterized by impaired:

26. The most common cause of iron deficiency anemia in an adult male is:

27. Beta-thalassemia major commonly causes:

28. Vitamin B12 is absorbed primarily in the:

29. Hemolytic anemia typically causes increased:

30. A major complication of sickle cell disease is: