Integrated Immunopathology, Immunodeficiency & Transplant — Hematopathology

Integrated Immunopathology, Immunodeficiency & Transplant MCQs: practice questions

Sample Integrated Immunopathology, Immunodeficiency & Transplant multiple-choice questions from Hematopathology.

1. A patient with chronic granulomatous disease is particularly susceptible to infections by:

   • A. Catalase-positive organisms
   • B. Only encapsulated viruses
   • C. Only anaerobic bacteria
   • D. Only fungi without catalase
   • E. Only spirochetes

2. Chronic granulomatous disease is caused by defective:

   • A. AIRE
   • B. HLA class II expression
   • C. C1 esterase inhibitor
   • D. NADPH oxidase
   • E. Bruton's tyrosine kinase

3. Myasthenia gravis is caused by antibodies directed against:

   • A. The acetylcholine receptor or related postsynaptic proteins
   • B. Type IV collagen
   • C. Double-stranded DNA
   • D. TSH only
   • E. PLA2R

4. Poststreptococcal glomerulonephritis is an example of:

   • A. No immune mechanism
   • B. Type IV hypersensitivity
   • C. Type III hypersensitivity
   • D. Type I hypersensitivity
   • E. Type II hypersensitivity only

5. A patient with SLE develops proteinuria and hematuria. The renal lesion is most likely:

   • A. Papillary necrosis
   • B. Minimal change disease only
   • C. Renal cell carcinoma
   • D. Hydronephrosis
   • E. Lupus nephritis

6. Type II hypersensitivity can cause tissue injury through:

7. Type I hypersensitivity requires prior sensitization and production of:

8. Chronic transplant rejection commonly features:

9. A child with recurrent infections has absent or severely reduced thymic tissue, hypocalcemia, and cardiac anomalies. The diagnosis is:

10. Tuberculin skin testing is an example of:

11. Familial Mediterranean fever predisposes to:

12. Graft-versus-host disease occurs when:

13. A patient with recurrent sinopulmonary infections and very low immunoglobulins has X-linked agammaglobulinemia. The underlying defect is in:

14. Acute cellular transplant rejection is primarily mediated by:

15. Systemic lupus erythematosus commonly produces immune-complex deposition in the:

16. Autoimmune lymphoproliferative syndrome is associated with defective:

17. Major target organs in acute graft-versus-host disease are:

18. Dialysis-associated amyloidosis is associated with deposition of:

19. A patient with severe combined immunodeficiency develops persistent opportunistic infections. The key pathologic problem is:

20. AL amyloid is derived from:

21. Anaphylaxis is caused by systemic:

22. Graves disease is an example of antibody-mediated stimulation of:

23. Common variable immunodeficiency is characterized by:

24. Amyloid is defined by deposition of:

25. Hyperacute transplant rejection results from:

26. Severe combined immunodeficiency causes severe impairment of:

27. Hashimoto thyroiditis is associated with antibodies against:

28. Selective IgA deficiency most strongly predisposes to:

29. Anti-dsDNA antibodies are particularly useful in SLE because they correlate with:

30. AA amyloid is associated with: