Integrated Endocrine Pathology — Endocrine

Integrated Endocrine Pathology MCQs: practice questions

Sample Integrated Endocrine Pathology multiple-choice questions from Endocrine.

1. A renal-adrenal mass in a patient with VHL syndrome is accompanied by a catecholamine-producing tumor. The adrenal tumor is:

   • A. Pheochromocytoma
   • B. Adrenal cortical carcinoma
   • C. Ganglioneuroma
   • D. Neuroblastoma
   • E. Adrenal cortical adenoma

2. A patient with autoimmune adrenalitis has hyperpigmentation and hypotension. The diagnosis is:

   • A. Pheochromocytoma
   • B. Primary hyperaldosteronism
   • C. Secondary adrenal insufficiency
   • D. Cushing disease
   • E. Primary adrenal insufficiency

3. A patient with severe hypothyroidism develops non-pitting edema. The diagnosis is:

   • A. Thyroid storm
   • B. Cushing syndrome
   • C. Myxedema
   • D. Acromegaly
   • E. Addison disease

4. A patient develops acute adrenal insufficiency after bilateral adrenal hemorrhage. Which electrolyte pattern is expected?

   • A. Normal electrolytes in every case
   • B. Hypernatremia and hyperkalemia
   • C. Hypercalcemia and hypokalemia
   • D. Hyponatremia and hyperkalemia
   • E. Hypernatremia and hypokalemia

5. An endocrine tumor syndrome featuring parathyroid, pituitary, and pancreatic neuroendocrine tumors is:

   • A. MEN 2A
   • B. MEN 2B
   • C. VHL syndrome
   • D. MEN 1
   • E. Li-Fraumeni syndrome

6. An elderly patient has a rapidly enlarging thyroid mass causing dysphagia and airway compression. The most likely diagnosis is:

7. A patient with medullary thyroid carcinoma should be evaluated for a mutation in:

8. A patient has enlarged hands, coarse facial features, and increased IGF-1. The underlying pituitary lesion is most likely:

9. A patient has hyperthyroidism, diffuse thyroid enlargement, and exophthalmos. The diagnosis is:

10. A patient has hypertension, hypokalemia, and suppressed renin. Which adrenal disorder is most likely?

11. A patient with pancreatic neuroendocrine tumor develops diabetes and gallstones. The tumor is:

12. A patient with pancreatic neuroendocrine tumor develops watery diarrhea and hypokalemia. The tumor is:

13. A patient with polyuria has low ADH due to posterior pituitary dysfunction. The diagnosis is:

14. A large pituitary mass causes bitemporal hemianopia. The structure compressed is the:

15. Postpartum hemorrhage is followed by failure to lactate and amenorrhea. The likely diagnosis is:

16. A patient with a thyroid nodule has nuclear grooves and psammoma bodies. The diagnosis is:

17. A child with adrenal hyperplasia has virilization and elevated 17-hydroxyprogesterone. The defect is most likely:

18. A thyroid tumor invades its capsule and blood vessels. The most likely diagnosis is:

19. MEN 2B is distinguished from MEN 2A by the presence of:

20. A patient with autoimmune thyroiditis develops a thyroid mass. Which malignancy is particularly associated?

21. A patient with MEN 2A is most likely to have medullary thyroid carcinoma, pheochromocytoma, and:

22. A patient with a pituitary adenoma has markedly elevated prolactin and galactorrhea. The tumor is:

23. A patient has weight gain, proximal muscle weakness, hypertension, and hyperglycemia due to a pituitary ACTH adenoma. The diagnosis is:

24. A thyroid tumor contains calcitonin-producing cells and amyloid stroma. The diagnosis is:

25. A patient with pancreatic neuroendocrine tumor develops necrolytic migratory erythema. The tumor is:

26. A patient has episodic headache, sweating, palpitations, and severe hypertension. The most likely tumor is:

27. A patient with acromegaly has elevated GH and IGF-1. Which finding is expected pathologically?

28. A patient with fasting hypoglycemia has inappropriately elevated insulin and C-peptide. The likely tumor is:

29. A patient with recurrent peptic ulcers and markedly elevated gastrin has a pancreatic neuroendocrine tumor. The diagnosis is:

30. A patient with MEN 1 has hypercalcemia, a pituitary adenoma, and recurrent peptic ulcers. The pancreatic tumor is most likely: