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Antidepressants — CNS Pharmacology

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Antidepressants
CNS Pharmacology · Antidepressants · medium
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Antidepressants MCQs: practice questions

Sample Antidepressants multiple-choice questions from CNS Pharmacology.

  1. Which antidepressant is used infrequently to suppress enuresis?

    • A. Fluoxetine
    • B. Bupropion
    • C. Venlafaxine
    • D. Imipramine
    • E. Trazodone
  2. Which antidepressant is associated with rare hepatotoxicity and hepatic failure?

    • A. Fluoxetine
    • B. Sertraline
    • C. Bupropion
    • D. Nefazodone
    • E. Desipramine
  3. Which adverse effect is characteristic of tricyclic antidepressants because of muscarinic blockade?

    • A. Hyperkalemia
    • B. Dry mouth
    • C. Miosis
    • D. Diarrhea
    • E. Hypersalivation
  4. Which antidepressant is associated with priapism?

    • A. Fluoxetine
    • B. Bupropion
    • C. Venlafaxine
    • D. Desipramine
    • E. Trazodone
  5. Which treatment is used for serious cardiac toxicity from TCA overdose?

    • A. Flumazenil
    • B. Naloxone
    • C. Sodium bicarbonate
    • D. Benztropine
    • E. Bromocriptine
  6. Which antidepressant is FDA approved for obsessive-compulsive disorder along with fluvoxamine?

  7. Which antidepressant class selectively inhibits the serotonin transporter?

  8. What potentially fatal complication can result when SSRIs are combined with other agents that increase serotonergic activity?

  9. Which antidepressant blocks primarily 5-HT2 receptors?

  10. Which antidepressant is especially associated with initial weight loss followed in some patients by weight gain?

  11. Which SSRIs inhibit CYP2D6 and can potentiate drugs metabolized by this enzyme?

  12. Which antidepressant class irreversibly inhibits MAO-A and MAO-B?

  13. Which SNRI requires particular caution in hepatic impairment?

  14. Which antidepressant class is generally preferred over TCAs because of more limited toxicity?

  15. Which SSRI is listed for premenstrual dysphoric disorder?

  16. Which antidepressant is a secondary-amine TCA?

  17. Which antidepressant is the active secondary-amine metabolite of amitriptyline?

  18. Which antidepressant class is more likely than SSRIs to cause anticholinergic and cardiovascular adverse effects?

  19. Which adverse effect is a leading cause of noncompliance with SSRIs?

  20. Which antidepressant has relatively little sexual dysfunction and little anticholinergic or hypotensive activity?

  21. Which SSRI has the longest half-life because of a long-acting active metabolite?

  22. Which antidepressant has increased seizure risk, especially at high therapeutic doses?

  23. Which antidepressant class inhibits both serotonin and norepinephrine transporters?

  24. Which antidepressant is commonly used for smoking cessation?

  25. Which antidepressant is associated with marked weight gain?

  26. Which adverse effect is more characteristic of SNRIs because of increased norepinephrine activity?

  27. Which antidepressant is particularly useful when depression is accompanied by insomnia because of marked sedation?

  28. Which antidepressant class is often used for neuropathic pain?

  29. How long can MAO inhibition persist after phenelzine or tranylcypromine has been eliminated from the body?

  30. Which SSRI is particularly associated with discontinuation symptoms because of its relatively short half-life?

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