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Parkinson Disease Drugs — CNS Pharmacology

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Parkinson Disease Drugs
CNS Pharmacology · Parkinson Disease Drugs · medium
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Parkinson Disease Drugs MCQs: practice questions

Sample Parkinson Disease Drugs multiple-choice questions from CNS Pharmacology.

  1. Which drug is a COMT inhibitor used in combination with levodopa?

    • A. Selegiline
    • B. Rasagiline
    • C. Amantadine
    • D. Benztropine
    • E. Entacapone
  2. Which drug is listed as a dopamine agonist rather than an enzyme inhibitor?

    • A. Entacapone
    • B. Selegiline
    • C. Carbidopa
    • D. Tolcapone
    • E. Ropinirole
  3. Which drug promotes dopamine release and has antiparkinsonian activity?

    • A. Carbidopa
    • B. Entacapone
    • C. Benztropine
    • D. Amantadine
    • E. Tolcapone
  4. Why does levodopa improve Parkinson disease symptoms?

    • A. It directly blocks muscarinic receptors
    • B. It inhibits acetylcholinesterase
    • C. It blocks dopamine receptors
    • D. It prevents dopamine synthesis
    • E. It increases dopamine available in the CNS
  5. Which drug can be added to levodopa to reduce its peripheral metabolism by COMT?

    • A. Entacapone
    • B. Benztropine
    • C. Bromocriptine
    • D. Trihexyphenidyl
    • E. Amantadine
  6. Which drug is an antimuscarinic agent used for parkinsonian symptoms?

  7. Which symptom reflects slowed initiation and execution of movement in Parkinson disease?

  8. Which antiparkinsonian drug is a dopamine receptor agonist?

  9. Which enzyme converts levodopa to dopamine?

  10. Which drug is another antimuscarinic used for Parkinson disease?

  11. Which drug is a peripheral dopa decarboxylase inhibitor that does not need to enter the brain to be useful?

  12. Which drug inhibits MAO-B and thereby decreases dopamine metabolism?

  13. Which drug is listed as an MAO-B inhibitor for Parkinson disease rather than a COMT inhibitor?

  14. What is the principal neuronal abnormality underlying idiopathic Parkinson disease?

  15. Which combination is a standard formulation used to increase central dopamine activity?

  16. Which drug acts by inhibiting catechol-O-methyltransferase rather than monoamine oxidase?

  17. Which drug would be expected to act directly at dopamine receptors rather than serve as a dopamine precursor?

  18. Which therapeutic strategy attempts to restore the dopamine-acetylcholine balance in the corpus striatum?

  19. Which drug is another dopamine agonist used in Parkinson disease?

  20. Which drug is classified as an antimuscarinic antiparkinsonian agent?

  21. Which drug reduces cholinergic activity and can help restore the dopamine-acetylcholine balance in the striatum?

  22. Which antiparkinsonian drug is particularly associated with hepatotoxicity severe enough to limit routine use?

  23. Which symptom is characteristic of idiopathic Parkinson disease?

  24. Which newer MAO-B inhibitor is listed for Parkinson disease?

  25. Which COMT inhibitor is limited by concern for hepatic necrosis?

  26. Which drug combination is marketed as Stalevo?

  27. Which drug is the metabolic precursor that can cross the blood-brain barrier and be converted to dopamine?

  28. A patient develops parkinsonian symptoms while taking a high-potency antipsychotic. Which mechanism best explains this adverse effect?

  29. Which drug acts by inhibiting an enzyme responsible for dopamine degradation?

  30. Why is carbidopa combined with levodopa?

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