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Antipsychotic Drugs — CNS Pharmacology

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Antipsychotic Drugs
CNS Pharmacology · Antipsychotic Drugs · medium
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Antipsychotic Drugs MCQs: practice questions

Sample Antipsychotic Drugs multiple-choice questions from CNS Pharmacology.

  1. Which antipsychotic is used for Tourette syndrome?

    • A. Clozapine
    • B. Olanzapine
    • C. Quetiapine
    • D. Ziprasidone
    • E. Haloperidol
  2. Which receptor blockade most directly explains sedation caused by many antipsychotic agents?

    • A. D2 agonism
    • B. β2 blockade
    • C. 5-HT3 agonism
    • D. Histamine H1 blockade
    • E. M2 stimulation
  3. Which antipsychotic formulation provides a long-acting depot preparation?

    • A. Chlorpromazine hydrochloride
    • B. Haloperidol decanoate
    • C. Risperidone oral solution
    • D. Clozapine tablet
    • E. Ziprasidone capsule
  4. Which typical antipsychotic is commonly used for severe nausea and vomiting because of D2 blockade in the chemoreceptor trigger zone?

    • A. Prochlorperazine
    • B. Risperidone
    • C. Clozapine
    • D. Aripiprazole
    • E. Quetiapine
  5. Atypical antipsychotic activity is also correlated with antagonism at which serotonin receptor?

    • A. 5-HT1A receptor
    • B. 5-HT2A receptor
    • C. 5-HT3 receptor
    • D. 5-HT4 receptor
    • E. 5-HT7 receptor
  6. Which antipsychotic adverse effect is characterized by hyperthermia, rigidity, diaphoresis, and autonomic instability?

  7. Which receptor blockade explains dry mouth and blurred vision with antipsychotic drugs?

  8. Which adverse effect is more likely with low-potency typical antipsychotics than high-potency agents?

  9. The therapeutic effect of typical antipsychotic drugs correlates best with antagonism at which receptor?

  10. A patient develops sustained muscle spasms and abnormal postures during the first week of haloperidol therapy. What is the likely adverse effect?

  11. Which atypical antipsychotic is particularly associated with QTc prolongation?

  12. Which antipsychotic is specifically associated with photosensitivity and pigmentation?

  13. Which typical antipsychotic is more likely to cause sedation and postural hypotension because it is low potency?

  14. Which antipsychotic is reserved for treatment-resistant schizophrenia and is notable for reduced extrapyramidal effects?

  15. Which extrapyramidal adverse effect usually develops after months to years of antipsychotic exposure?

  16. Which antipsychotic is associated with increased prolactin because of dopamine D2 antagonism?

  17. Which antipsychotic is associated with agranulocytosis?

  18. A patient taking an antipsychotic is unable to sit still and has intense motor restlessness. What is the most likely diagnosis?

  19. Which antipsychotic is reserved primarily for treatment-resistant schizophrenia because of a serious blood dyscrasia risk?

  20. Which atypical antipsychotic is associated with marked weight gain and metabolic effects?

  21. Which receptor blockade can cause orthostatic hypotension and reflex tachycardia?

  22. Which adverse effect of antipsychotic therapy can include galactorrhea and amenorrhea in women?

  23. Which adverse effect is caused by dopamine blockade in the basal ganglia?

  24. Which symptom is most characteristic of antipsychotic-induced parkinsonism?

  25. Which typical antipsychotic is a high-potency agent with a high likelihood of extrapyramidal reactions?

  26. Which drug can be used to control antipsychotic-induced akathisia?

  27. Which endocrine abnormality can result from dopamine D2 blockade in the pituitary?

  28. Which drug is used to control acute dystonia caused by antipsychotic therapy?

  29. Which antipsychotic adverse effect is particularly associated with chlorpromazine?

  30. Which treatment is included for neuroleptic malignant syndrome?

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