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Corticosteroids — Endocrine Pharmacology
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Corticosteroids
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Corticosteroids MCQs: practice questions
Sample Corticosteroids multiple-choice questions from Endocrine Pharmacology.
Which glucocorticoid has an equivalent anti-inflammatory potency of approximately 30 relative to cortisol in the BRS table?
- A. Prednisone
- B. Cortisone
- C. Triamcinolone
- D. Dexamethasone
- E. Fludrocortisone
Which inflammatory mediators are reduced by glucocorticoids through annexin 1a-related effects?
- A. Thrombin and fibrin
- B. Prostaglandins and leukotrienes
- C. Insulin and glucagon
- D. TSH and T4
- E. Acetylcholine and dopamine
Which structural modification increases corticosteroid activity?
- A. Removal of the 17α-hydroxyl
- B. Addition of a 9α-fluoro group
- C. Removal of the steroid nucleus
- D. Addition of a phosphate group only
- E. Replacement of all carbons with nitrogen
Which adverse effect of glucocorticoids reflects suppression of normal immune defenses?
- A. Increased susceptibility to infection
- B. Increased resistance to all infections
- C. Enhanced delayed hypersensitivity
- D. Increased vaccine-independent immunity
- E. Persistent neutrophil destruction
Which effect on immunity is produced by glucocorticoids?
- A. Immunosuppression
- B. Enhanced antibody-independent immunity
- C. Increased cytokine production
- D. Increased leukocyte migration into all tissues
- E. Permanent activation of T cells
Which effect of glucocorticoids can impair wound healing?
Which effect is produced by mineralocorticoids in the kidney?
Which structural modification increases glucocorticoid activity without increasing mineralocorticoid activity?
Which tissue effect is associated with chronic glucocorticoid exposure?
Which clinical disorder is treated with glucocorticoids because of their immunosuppressive effects?
Failure to suppress cortisol after dexamethasone can suggest which disorder?
Which receptor mediates the genomic actions of glucocorticoids?
Which receptor mediates the primary renal actions of mineralocorticoids?
Which condition can be treated with glucocorticoids to accelerate fetal lung maturation?
Which glucocorticoid is converted in the liver to prednisolone?
Which adverse effect results from the mineralocorticoid component of some glucocorticoids?
Which synthetic glucocorticoid has high anti-inflammatory potency with very little sodium-retaining activity?
Which metabolic adverse effect is common with chronic glucocorticoid therapy?
Which ocular complication can result from chronic glucocorticoid therapy?
Which drug selectively causes atrophy of the zona fasciculata and zona reticularis?
Why must prolonged systemic glucocorticoid therapy generally be tapered rather than stopped abruptly?
Which adverse effect is characteristic of mineralocorticoid excess?
Which glucocorticoid has greater mineralocorticoid activity than dexamethasone?
Which drug inhibits 11-hydroxylase and reduces cortisol production?
Which mineralocorticoid is the agent of choice for long-term replacement therapy?
Which glucocorticoid is used in the dexamethasone suppression test?
Which mineralocorticoid is not orally administered?
Which adverse effect is characteristic of chronic glucocorticoid excess?
Which endogenous corticosteroid has both glucocorticoid and mineralocorticoid activity?
Which gastrointestinal adverse effect is associated with systemic glucocorticoids?