Integrated Renal & Genitourinary Pathology — Renal & Genitourinary

Integrated Renal & Genitourinary Pathology MCQs: practice questions

Sample Integrated Renal & Genitourinary Pathology multiple-choice questions from Renal & Genitourinary.

1. A patient has nephrotic syndrome and a renal biopsy shows diffuse capillary-wall thickening with subepithelial immune deposits. The diagnosis is:

   • A. IgA nephropathy
   • B. Minimal change disease
   • C. Membranous nephropathy
   • D. Poststreptococcal GN
   • E. Acute interstitial nephritis

2. A renal carcinoma extends from the kidney into the inferior vena cava. Which tumor is particularly known for this pattern?

   • A. Urothelial papilloma
   • B. Angiomyolipoma
   • C. Oncocytoma
   • D. Renal cell carcinoma
   • E. Wilms tumor

3. A renal tumor consists of pale cells with distinct cell borders and prominent cell membranes. The most likely diagnosis is:

   • A. Angiomyolipoma
   • B. Chromophobe renal cell carcinoma
   • C. Clear cell RCC
   • D. Wilms tumor
   • E. Papillary RCC

4. A patient develops nephritic syndrome after a recent streptococcal pharyngitis. Which electron microscopic finding is expected?

   • A. Papillary necrosis
   • B. Subepithelial humps
   • C. Amyloid fibrils
   • D. Diffuse foot-process effacement only
   • E. Linear GBM splitting

5. A patient with a renal mass develops polycythemia. Which paraneoplastic mediator is most likely responsible?

   • A. Insulin
   • B. Calcitonin
   • C. Erythropoietin
   • D. ADH
   • E. Parathyroid hormone

6. A patient with nephrotic syndrome has segmental sclerosis in some glomeruli. The diagnosis is:

7. A patient with long-standing diabetes develops albuminuria and progressive renal insufficiency. Which lesion is most characteristic?

8. A patient taking a new antibiotic develops fever, rash, eosinophilia, and acute kidney injury. The most likely diagnosis is:

9. A patient with analgesic nephropathy develops papillary necrosis. Which other condition has a similar association?

10. A patient has recurrent urinary tract infections and an irregularly scarred kidney with blunted calyces. The diagnosis is:

11. A patient develops acute kidney injury after severe hypotension and has muddy brown casts. The diagnosis is:

12. A patient from an endemic area has chronic Schistosoma haematobium infection and develops a bladder mass. Which malignancy is particularly associated?

13. A child has a renal mass with blastemal, epithelial, and stromal components. The diagnosis is:

14. A patient with systemic amyloidosis develops heavy proteinuria. Which renal biopsy finding supports the diagnosis?

15. A patient with severe bladder outlet obstruction develops bilateral hydronephrosis. The renal damage is primarily caused by:

16. A patient with cystinuria develops recurrent stones. Which crystal shape is characteristic?

17. A patient with chronic hypertension develops small kidneys and progressive renal insufficiency. The most likely underlying lesion is:

18. A patient with flank pain and hematuria has a renal mass containing macroscopic fat. The most likely tumor is:

19. A renal tumor shows papillary architecture and is associated with MET pathway alterations. The diagnosis is:

20. A patient has hematuria, pulmonary hemorrhage, and linear IgG deposition along the glomerular basement membrane. The diagnosis is:

21. A patient has recurrent renal colic and a stone that is composed of calcium oxalate. Which urinary finding is most likely?

22. An adult has a renal mass composed of clear cells and a VHL-associated molecular abnormality. The diagnosis is:

23. A patient presents with painless gross hematuria and has a history of heavy cigarette smoking. The most likely diagnosis is:

24. A flat, high-grade urothelial lesion with severe cytologic atypia throughout the mucosa is:

25. A patient with autosomal dominant polycystic kidney disease develops sudden severe headache. Which complication should be considered?

26. A child develops edema and heavy proteinuria but normal renal function. Light microscopy is essentially normal. The diagnosis is:

27. A young adult has recurrent episodes of gross hematuria within days of upper respiratory infections. The most likely diagnosis is:

28. A patient with long-standing obstruction develops progressive renal atrophy. Which finding is most likely?

29. A patient with recurrent Proteus urinary infections develops a large branching renal calculus. The stone is most likely:

30. A patient with autosomal recessive polycystic kidney disease has renal cysts and congenital hepatic fibrosis. The cysts primarily involve the: